Research Scientists

Jerome H. Jaffe

Jerome H. Jaffe
Senior Research Scientist

Degree: M.D., Temple University School of Medicine
Phone: 410-837-3977
Fax: 410-752-4218
Email:


Research Interests

Dr. Jaffe is Clinical Professor of Psychiatry in the Division of Alcohol and Drug Abuse, University of Maryland School of Medicine, and Adjunct Professor, Department of Mental Health, Johns Hopkins Bloomberg School of Public Health. He is internationally recognized as an expert on the addictions. He has worked in this area for more than forty years, in academia and government, as a clinician, laboratory and clinical researcher, teacher, writer, and policymaker. As the first White House "Drug Czar," Dr. Jaffe initiated many of the basic and epidemiological research programs that formed the groundwork for ongoing efforts in drug abuse research, and he introduced programs that radically altered and expanded drug abuse treatment in the United States. His more than 200 publications include peer reviewed articles in scientific journals, chapters in major textbooks of psychiatry, pharmacology, and drug abuse, and books and articles in the popular press. Dr. Jaffe is on the editorial boards of several journals, has served on national and international advisory groups, and is a consultant to private and public agencies concerned with drug abuse treatment and policy. He is a Fellow of the American Psychiatric Association (Distinguished Life), American College of Neuropsychopharmacology (Emeritus), American Academy of Addiction Psychiatry, College on Problems of Drug Dependence, and Honorary Fellow of the Royal College of Psychiatrists and the Society for the Study of Addiction in the UK.

PBS Frontline Series on Addiction Interview

Selected Publications

Gryczynski, J., Jaffe, J. H., Schwartz, R. P., Dusek, K. A., Gugsa, N., Monroe, C. L., O’Grady, K. E., Olsen, Y. K., & Mitchell, S. G. (in press). Patient perspectives on choosing buprenorphine over methadone in an urban equal access system. American Journal on Addictions.

Gryczynski, J., Mitchell, S. G., Jaffe, J. H., Kelly, S. M., Myers, C., O'Grady K, E., Olsen, Y. K., & Schwartz, R. P. (in press). Retention in methadone and buprenorphine treatment among African Americans. Journal of Substance Abuse Treatment.

Mitchell, S., Gryczynski, J., Kelly, S., O'Grady, K., Jaffe, J., & Olsen, Y. (in press). Treatment outcomes of African American buprenorphine patients by parole and probation status. Journal of Drug Issues.

Schwartz, R. P., Gryczynski, J., O’Grady, K. E., Sharfstein, J. M., Warren, G., Olsen, Y., Mitchell, S. G., & Jaffe, J. H. (in press). Opioid agonist treatments and heroin overdose deaths in Baltimore, Maryland from 1995-2009: a tale of expansion and reduction. American Journal of Public Health.

Kelly, S. M., O'Grady, K. E., Jaffe, J. H., Gandhi, D., & Schwartz, R. P. (2013). Improvements in outcomes in methadone patients on  probation/parole regardless of counseling early in treatment. Journal of Addiction Medicine, 7(2), 133-138.

Mitchell, S. G., Gryczynski, J., Schwartz, R. P., O'Grady, K. E., Olsen, Y. K., & Jaffe, J. H. (2013). A randomized trial of intensive outpatient (IOP) vs. standard outpatient (OP) buprenorphine treatment for African Americans. [Research Support, N.I.H., Extramural]. Drug and Alcohol Dependence, 128(3), 222-229.

Kelly, S. M., Schwartz, R. P., O'Grady K, E., Gandhi, D., & Jaffe, J. H. (2012). Impact of Methadone With Versus Without Drug Abuse Counseling on HIV Risk: 4- and 12-Month Findings From a Clinical Trial. Journal of Addiction Medecine, 6(2), 145-152. [PMCID: PMC3322294].

Mitchell, S. G., Kelly, S. M., Gryczynski, J., Myers, C. P., Jaffe, J. H., O'Grady, K. E., Olsen, Y. K., & Schwartz, R. P. (2012). African American patients seeking treatment in the public sector: Characteristics of buprenorphine vs. methadone patients. Drug and Alcohol Dependence, 122, 55-60. [PMCID: PMC3251709].

Schwartz, R. P., Kelly, S. M., O'Grady, K. E., Gandhi, D., & Jaffe, J. H. (2012). Randomized trial of standard methadone treatment compared to initiating methadone without counseling: 12-month findings. Addiction, 107(5), 943-952. [PMCID: PMC3319854].

Gryczynski, J., Schwartz, R. P., Salkever, D. S., Mitchell, S. G., & Jaffe, J. H. (2011). Patterns in admission delays to outpatient methadone treatment in the United States. Journal of Substance Abuse Treatment, 41(4), 431-439 [PMCID: PMC3205308].

Schwartz, R. P., Kelly, S. M., O'Grady, K. E., Gandhi, D., & Jaffe, J. H. (2011). Interim methadone treatment compared to standard methadone treatment: 4-Month findings. Journal of Substance Abuse Treatment, 41(1), 21-29 [PMCID: PMC3110526].

Wilson, M. E., Schwartz, R. P., O'Grady, K. E., & Jaffe, J. H. (2010). Impact of interim methadone maintenance on HIV risk behaviors. Journal of Urban Health, 87(4), 586-591. [PMCID: PMC2900571].

Gryczynski, J., Schwartz, R., O'Grady, K., & Jaffe, J. (2009a). Treatment entry among individuals on a waiting list for methadone maintenance. American Journal of Drug and Alcohol Abuse, 35(5), 290-294. [PMCID: PMC2916645].

Gryczynski, J., Schwartz, R. P., O’Grady, K., & Jaffe, J. H. (2009b). Dropout from interim methadone and subsequent comprehensive methadone maintenance. American Journal of Drug & Alcohol Abuse, 35(6), 394-398.

Schwartz, R. P., Jaffe, J. H., O'Grady, K. E., Kinlock, T. W., Gordon, M. S., Kelly, S. M., Wilson, M. E., & Ahmed, A. (2009). Interim methadone treatment: impact on arrests. Drug and Alcohol Dependence, 103(3), 148-154 [PMCID: PMC2699328].

Schwartz, R. P., Jaffe, J. H., O'Grady, K., Das, B., Highfield, D. A., & Wilson, M. E. (2009). Scaling-up Interim Methadone Maintenance: Treatment for 1,000 Heroin Addicts. Journal of Substance Abuse Treatment, 37(4), 362-367. [PMCID: PMC2796977].

Schwartz, R. P., Jaffe, J. H., Highfield, D. A., Callaman, J. M., & O'Grady, K. E. (2007). A randomized controlled trial of interim methadone maintenance: 10-Month follow-up. Drug and Alcohol Dependence, 86(1), 30-36.

Schwartz, R. P., Highfield, D. A., Jaffe, J. H., Brady, J. V., Butler, C. B., Rouse, C. O., Callaman, J. M., O'Grady, K. E., & Battjes, R. J. (2006). A randomized controlled trial of interim methadone maintenance. Archives of General Psychiatry, 63(1), 102-109.

Jaffe, J. H., Knapp, C. M., & Ciraulo, D. A. (2005). Opiates: Clinical Aspects. In J. H. Lowinson, P. Ruiz, R. B. Millman & J. G. Langrod (Eds.), Substance Abuse: A Comprehensive Textbook (pp. 158-165). Philadelphia, PA: Lippincott Williams & Wilkins.

Gandhi, D. H., Jaffe, J. H., McNary, S., Kavanagh, G. J., Hayes, M., & Currens, M. (2003). Short-term outcomes after brief ambulatory opioid detoxification with buprenorphine in young heroin users. Addiction, 98(4), 453-462.

Jaffe, J. H., & O'Keeffe, C. (2003). From morphine clinics to buprenorphine: regulating opioid agonist treatment of addiction in the United States. Drug and Alcohol Dependence, 70(2 Suppl), S3-11.

Jaffe, J. H. (2001). Injectable opiate maintenance in the United Kingdom: a view from the United States. [Comment]. Addiction, 96(4), 557-560; discusion 564-555.

Johnson, R. E., Jaffe, J. H., & Fudala, P. J. (1992). A controlled trial of buprenorphine treatment for opioid dependence. Journal of the American Medical Association, 267(20), 2750-2755.

Vocci, F. J., Jaffe, J. H., & Jain, R. B. (1992). Drug dependence (addiction) and its treatment. [Review]. NIDA Research Monograph, 128, 6-13.

Witkin, J. M., Johnson, R. E., Jaffe, J. H., Goldberg, S. R., Grayson, N. A., Rice, K. C., & Katz, J. L. (1991). The partial opioid agonist, buprenorphine, protects against lethal effects of cocaine. Drug and Alcohol Dependence, 27(2), 177-184.

Fudala, P. J., Jaffe, J. H., Dax, E. M., & Johnson, R. E. (1990). Use of buprenorphine in the treatment of opioid addiction. II. Physiologic and behavioral effects of daily and alternate-day administration and abrupt withdrawal. Clinical Pharmacology and Therapeutics, 47(4), 525-534.

Jaffe, J. H., Kanzler, M., Brady, R., & Friedman, L. (1982). Methodology for assessing agents that suppress methadone withdrawal: a study of baclofen. NIDA Research  Monograph, 41, 269-275.

Senay, E., Jaffe, J., diMenza, S., & Renault, P. (1973). A 48-week study of methadone, methadyl acetate and minimal services. In S. Fisher & A. M. Freedman (Eds.), Opiate Dependence: Origins and Treatment. New York: Halsted Press.

Jaffe, J. H., Senay, E. C., Schuster, C. R., Renault, P. R., Smith, B., & DiMenza, S. (1972). Methadyl acetate vs methadone. A double-blind study in heroin users. Journal of the American Medical Association, 222(4), 437-442.

Jaffe, J. H., & Senay, E. C. (1971). Methadone and l-methadyl acetate. Use in management of narcotics addicts. Journal of the American Medical Association, 216(8), 1303-1305.

Jaffe, J. H., Fritz, K., & Kaistha, K. K. (1971). Methadone disks. Injectable-noninjectable tablets. Archives of  General Psychiatry, 25(6), 525-526.

Schuster, C. R., Smith, B. B., & Jaffe, J. H. (1971). Drug abuse in heroin users. An experimental study of self administration of methadone, codeine, and pentazocine. Archives of General Psychiatry, 24(4), 359-362.

Jaffe, J. H., Schuster, C. R., Smith, B. B., & Blachley, P. H. (1970). Comparison of acetylmethadol and methadone in the treatment of long-term heroin users. A pilot study. Journal of the American Medical Association, 211(11), 1834-1836.

Jaffe, J., Zaks, M., & Washington, E. (1969). Experience with the use of methadone in a multi-modality program for the treatment of narcotic users. Substance Use & Misuse, 4(3), 481-490.