Research Interests

Dr. Jaffe is Clinical Professor of Psychiatry in the Division of Alcohol and Drug Abuse, University of Maryland School of Medicine, and Adjunct Professor, Department of Mental Health, Johns Hopkins Bloomberg School of Public Health.  He is internationally recognized as an expert on the addictions.  He has worked in this area for more than forty years, in academia and government, as a clinician, laboratory and clinical researcher, teacher, writer, and policymaker.  As the first White House “Drug Czar,” Dr. Jaffe initiated many of the basic and epidemiological research programs that formed the groundwork for ongoing efforts in drug abuse research, and he introduced programs that radically altered and expanded drug abuse treatment in the United States.  His more than 200 publications include peer reviewed articles in scientific journals, chapters in major textbooks of psychiatry, pharmacology, and drug abuse, and books and articles in the popular press.  Dr. Jaffe is on the editorial boards of several journals, has served on national and international advisory groups, and is a consultant to private and public agencies concerned with drug abuse treatment and policy.  He is a Fellow of the American Psychiatric Association (Distinguished Life), American College of Neuropsychopharmacology (Emeritus), American Academy of Addiction Psychiatry, College on Problems of Drug Dependence, and Honorary Fellow of the Royal College of Psychiatrists and the Society for the Study of Addiction in the UK.

Selected Publications

Schwartz RP, Jaffe JH, Highfield DA, Callaman JM, O’Grady KE. A randomized controlled trial of interim methadone maintenance: 10-month follow-up. Drug and Alcohol Dependence, 2007; 86:30-36.

Schwartz, R.P., Highfield, D.A., Jaffe, J.H., Brady, J.V., Butler, C.A., Rouse, C.O., Callaman, J.M., O’Grady, K.E., Battjes, R.J. A Randomized Controlled Trial of Interim Methadone Maintenance. Archives of General Psychiatry, 2006; 63:102-109

Gandhi DH, Jaffe JH, McNary S, Kavanagh GJ, Hayes M, Currens M. Short-term outcomes after brief ambulatory opioid detoxification with buprenorphine in young heroin users. Addiction. 2003 Apr;98(4):453-62.

Jaffe JH, O'Keeffe C. From morphine clinics to buprenorphine: regulating opioid agonist treatment of addiction in the United States. Drug Alcohol Depend. 2003 May 21;70 (2 Suppl):S3-S11.

Jaffe JH. Injectable opiate maintenance in the United Kingdom: a view from the United States.Addiction. 2001 Apr; 96(4):557-60; discussion 564-5.

Jaffe JH. Conversation with Jerome H. Jaffe. Addiction. 1999 Jan; 94(1):13-30.

Vocci, F.J., Jaffe, J.H., Jain, R.B. Drug dependence (addiction) and its treatment. In: Jain, R.B., ed., Statistical issues in clinical trials for treatment of opiate dependence. NIDA Res. Monogr. 128: 6-13, 1992.

Johnson, R.E., Jaffe, J.H., Fudala, P.J. A controlled trial of buprenorphone treatment for opioid dependence. JAMA 267: 2750-2755, 1992.

Fudula, P.J., Johnson, R.E., Jaffe, J.H., Outpatient comparison of buprenorphine and methadone maintenance. I. Effects on opiate use and self-reported adverse effects and withdrawal symptomatology. (Abstract) NIDA Res. Monogr. 105: 587-588, 1991.

Witkin, J.M., Johnson, R.E., Jaffe, J.H., Goldberg, S.R., Grayson, N.A., Rice, K.C., Katz, J.L. The partial opioid agonist, buprenorphine, protects against lethal effects of cocaine. Drug Alcohol Depend. 27: 177-184, 1991.

Fudala, P.J., Jaffe, J.H., Dax, E.M., and Johnson, R.E. Use of buprenorphine in the treatment of opioid addiction. II. Effects of daily and alternate-day administration and abrupt withdrawal. Clin. Pharmacol. Ther. 47: 525-534, 1990.

Jaffe, J.H., Kanzler, M., Brady, R., Friedman, L. Methodology for assessing agents that suppress methadone withdrawal: a study of Baclofen. NIDA Res. Monogr. 41: 269-275, 1982.

Senay, E.C., Jaffe, J.H., diMenza, S., Renault, P.F. A 48-week study of methadone, methadyl acetate and minimal services. In: Fisher, S., Freedman, A.M., eds., Opiate Dependence: Origins and Treatment. New York, Halsted Press, 1973.

Jaffe, J.H., Senay, E.C., Schuster, C.R., Renault, P.F., Smith, B., diMenza, S. Methadyl acetate vs. methadone: A double-blind study in heroin users. JAMA 222(4): 437-442, 1972.

Jaffe, J.H., Fritz, K., Kaistha, K.K. Methadone disks: Injectable & non-injectable tablets. Arch. Gen.Psychiatry 25(6): 525-526, 1971.

Jaffe, J.H. , Senay, E.C. Methadone and 1-methadyl acetate, use in management of narcotics addicts. JAMA 216(8): 1303-1305, 1971.

Schuster, C.R., Jaffe, J.H., Smith, B. Drug abuse in heroin users: An experimental study of self administration of methadone, codeine, and pentazocine. Arch. Gen. Psychiatry 24: 359-362, 1971.

Jaffe, J.H., Schuster, C.R., Smith, B., Blachly, P. A comparison of acetylemethadol and methadone in the treatment of chronic heroin users. A pilot study. JAMA 211(11): 1834-1836, 1970.

Jaffe, J.H., Zaks, M., Washington, E. Experience with the use of methadone in a multi-modality program for the treatment of narcotic users. Internat. J. Addict. 4(3):481-490, 1969.